Astro Boy: Omega Factor is a video game for the GameBoy Advance handheld video game console, developed by Treasure and Hitmaker. It stars Astro in a plot lifted from several Astro Boy iterations. The action takes place as a horizontally scrolling shooter, with Astro Boy facing an onslaught of robotic enemies using the various weaponry at his disposal.
- The game was originally called "Astro Boy Tetsuwan Atom: Heart no Himitsu" (Astro Boy Tetsuwan Atom: The Heart's Secret".
- The western title is misleading, since Omega Factor is actually a hazardous device which gives an evil mind to a robot or even deprive it from its mind.
- Kokoro was renamed to Omega Factor, despite the fact Omega Factor is the opposite in the series actual canon.